Police were called shortly after 6am on (Saturday 5 January 2020) to a report of a collision on Trinity Way, Manchester.
A blue BMW M3 car was travelling along Trinity Way when it left the road and collided with the central reservation, sending the vehicle airborne before colliding with street furniture and landing on its roof.
The driver of the vehicle, a man aged 32, has been taken to hospital with injuries that are not believed to be life-threatening.
Two male passengers aged 31 and 33 have been taken to hospital with serious injuries which are not believed to be life-threatening.
Two further male occupants of the vehicle were taken to hospital with minor injuries.
No arrests have been made.
Trinity Way was closed for four hours while enquiries were carried out.
PC Steve Smith from GMP’s Serious Collision Investigation Unit said: “Two men have been left with serious injuries as a result of this collision.
“We wish them well as they undergo treatment.
“If you witnessed the vehicle prior to the collision please get in touch.
“We are also asking for anyone who has dashcam footage or CCTV footage around this area which may have captured the collision, or vehicle beforehand, to come forward.”
Anyone with information should call police on 0161 856 4741 or the independent charity Crimestoppers, anonymously, on 0800 555 111.