Police were called on September 7 at around 5am to reports of a burglary at McDonalds in Stretford.
Officers attended and found that an offender had deactivated an alarm before breaking a window to gain access to the premises.
Once inside, the offender located the safe and took a large amount of cash from it, before fleeing in an unknown direction.
Enquiries are ongoing to establish the full circumstances around this incident.
Anyone with information should contact police on 101, quoting incident number 271 of 07/09/17, or anonymously through the independent charity Crimestoppers on 0800 555 111.