At around 11.30am yesterday, (Wednesday 23 June) police were called to a report of a road traffic collision involving a lorry and two cars on the A57 at Cadishead Way, Irlam.
The air ambulance and fire service also attended and a 62-year-old man and a 39-year-old man were both taken to hospital in a critical condition.
The driver of the lorry remained at the scene to assist police. No arrests have been made.
Anyone with information should call the Serious Collision Investigation Unit on 0161 856 4741 quoting incident 1074 of 23/06/2021.
Anyone with information can also report online or by using the LiveChat function at www.gmp.police.uk.